TOP GUIDELINES OF TRASTUZUMAB HOW DOES IT WORK

The phosphorylated HER3 gives docking web sites for p85 subunit of PI3K. The entirely activated PI3K elaborate is created by binding of p110 subunit of PI3K to p85 which will be able to develop PIP3 by using phosphorylating the PIP2. AKT binds to PIP3 and it is phosphorylated by PDK1 and mTORC2. Phosphorylation of AKT at both of those threonine and